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Protests break out across Pak after ECP disqualifies Imran Khan_我的网站
A | 研究人员利用人工智能解码基因激活中的关键DNA序列。图片来源：美国加州大学圣迭戈分校官网 美国加州大学圣迭戈分校研究人员利用高通量DNA测序和人工智能技术，解码了人类基因中一段名为“起始子”的关键DNA序列特征。这项成果为解析基因表达调控规律和预测DNA突变影响提供了新工具。 Islamabad, Oct 21 (UNI) PTI leader Imran Khan’s disqualification from holding public offices by the Election Commission of Pakistan (ECP) on Friday steeped the country into agitation as angry PTI workers started protests against the decision, seen as a massive political blow to Khan's party.
Following the announcement of the verdict, chaotic scenes were witnessed outside the ECP office where enraged PTI workers converged in large numbers, chanting slogans against the government.
According to police sources, three major arteries leading to Islamabad have been blocked by the district administrator to avoid any untoward incident.
The Islamabad traffic police advised commuters to use Peshawar Road or Lehtrar Road as Chungi No 26 and Athal Chowk in Bhara Kahu area have been closed to all types of traffic due to the protests and security concerns.
In Peshawar, protesters blocked a road near Pir Zakordi bridge and another near Stadium Chowk. They also put traffic on hold after burning tyres on the Motorway near the toll plaza.
Meanwhile, in Karachi, protesters led by party leaders Ali Zaidi, Firdous Shamim Naqvi, Mehmood Moulvi, and others staged a sit-in outside the Sindh ECP office. Reportedly, PTI workers tried to force their way into the ECP building but were repelled by the police amid thunderous slogan-chanting.
In Charsadda protesters thronged the Farooq-e-Azam Chowk, where they were confronted by the ANP workers. Both sides shouted slogans against each other in the presence of a heavy contingent of police.
Swabi also emerged on the protest map after PTI cohorts barricaded the Mardan and Jehangir roads for traffic. Life in Shabqadar was also reported to have suffered from the PTI protests.
However, part of Mardan was seen cheering Imran Khan's disqualification by distributing sweets among each other. A poor labourer from Mardan in a video message said he was so happy that Khan was gone. "I am poor so I could only buy half a kg of sweetmeat," the labourer said.
According to Geo news reports pouring in from Naushehra, hundreds of fuming Khan fans crowded at Shawera Chowk and recorded their protest, which is currently underway.
Moreover, Mangora Road in Swat has also been closed by the protesters.
PTI's supporters have also kicked off a protest at Shahdra Chowk in Lahore.
On the contrary, Hafizabad, a PML-N stronghold, was a scene of celebration with the N-league workers rejoicing over the ECP's decision saying Imran Khan's chapter had finally come to an end.
PTI youths blocked the M5 Motorway near Billiwala area in Multan's suburbs, according to reports, while protesters sat in the middle of Delhi-Multan road in Vehari, bringing the heavy traffic to a halt.
UNI GNK。相关论文发表于最新一期《基因与发育》杂志。 人体不同类型的细胞虽然拥有基本相同的DNA，但由于被激活的基因不同，最终能够形成不同的细胞类型，并执行各自特定的功能。
B | DNA中的一些特殊片段负责精细调控基因表达，使细胞产生酶、激素、蛋白质以及维持细胞结构和功能所需的其他重要成分。如果这些基因没有被正确激活，细胞可能无法正常发挥功能，并可能引发包括癌症在内的多种疾病。 为了进一步弄清DNA中哪些序列负责启动基因表达，研究人员将目光投向了“起始子”。这是基因表达过程中的一个重要DNA区域，是基因编码的信息开始被表达，进而产生具有功能产物的关键区域。
C | 研究人员利用高通量DNA测序技术，检测了约50万个不同“起始子”序列的基因表达活性。随后，他们将这些实验数据用于训练机器学习模型，使AI能够识别“起始子”特有的DNA序列模式。 利用训练出的模型，研究人员进一步在人体基因中搜索“起始子”的特征序列，发现约60%的人类基因含有“起始子”。他们表示，这些AI模型首次能够预测人类基因中是否存在“起始子”，并解码其DNA碱基序列模式。相关数据和模型还可用于预测“起始子”相关DNA突变的影响，以及设计具有特定功能的合成启动子，即能够调控基因开启和关闭的DNA序列。 研究人员表示，人类每个细胞中都包含约60亿个DNA碱基，其中蕴含着决定基因何时、何地，以及以多大程度表达的复杂“密码”。此次建立的“起始子”AI模型只是解析这一基因表达“密码”的一小部分，希望未来进一步扩大模型范围，以更加全面地解析人类基因表达调控规律。（记者张佳欣）。
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Published on:02:32:17